If I had to reduce to one word what caused me to leave book publishing, it would be this: Dread.
There were so many kinds of dread as an editor. Dread of the not-great cover that you'd have to try to convince your author to accept. Dread of the not-great manuscript that might never become as great as you'd hoped. Dread of the terrible sales results for even the books that you thought were great. Dread of the times your publisher would walk by your office door and glance in with a disgusted expression on her face that exuded, "You're still here?" Dread of your days being numbered. Dread of the axe falling. Dread of trying to do anything else. So much dread.